Definitely you can mix source files in both OCaml and Reason, if that’s your question.
However, if you don’t have a baby duck syndrome for JS, I’m strongly recommend you to go with OCaml: Reason’s syntax is not very stable - authors can’t even decide whether to use ML-like or C-like style for a function application; see this thread.
OCaml syntax have it’s own drawbacks; but that’s not much a problem when you get used to it.
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